Virology & Mycology
Open Access
ISSN: 2161-0517
+44 1223 790975
ISSN: 2161-0517
+44 1223 790975
Elham Moasser and Afagh Moattari
Posters-Accepted Abstracts: Virol-mycol
Background: Influenza is one of the most important emerging and reemerging infectious diseases that cause significant mortality and morbidity in communities (epidemic) and worldwide (pandemic) and has been posing a threat to economy and public health. The aim of this study is to determine phylogenecity and heterogenecity of the antigenic variations in circulating influenza A/H1N1 and A/H3N2 virus isolates during 2014-2016 in Iran andcompare them with the vaccine strains that were recommended by WHO for the same period. Moreover, determination of drug resistance and influenza significant potential for manipulation are other aims of the current study. Methods: Clinical samples are collected from 200 individuals in Iran who are diagnosed with influenza illness between 2014 and 2016. Typing and sub-typing of the isolates are performed using multiplex RT-PCR and phylogenetic analysis is carried out for hemagglutinin, neuraminidase and matrix genes of the A/H1N1 and A/H3N2 isolates. Results: Forty out of 200 samples are positive for influenza A virus and no influenza B virus is detected until now. This study is in progress for more results. Conclusion: The synchronized seasonal patterns and high genetic diversity of influenza A viruses make possible to capture the evolutionary dynamic and epidemiological rules governing antigenic drift and reassortment and may serve as a �??�??warning�??�?? system that recapitulates the global epidemic. Our findings demonstrate that the A/H3N2 is the predominant sub-type of human influenza virus among the patients studied in Iran during 2014-2015. Our research is continued for viruses isolated in Iran between 2015 and 2016.