Development of Malaria Vaccines using an Alpahvirus Virus-Like Pa | 60205
Journal of Clinical Trials

Journal of Clinical Trials
Open Access

ISSN: 2167-0870

+44 7868 792050

Development of Malaria Vaccines using an Alpahvirus Virus-Like Particle (VLP) Platform

Webinar on 5th International Conference on Vaccines, Immunology and Clinical Trials

March 23-24, 2022 | Webinar

Wataru Akahata

Kyoto University, USA

Scientific Tracks Abstracts: J Clin Trials

Abstract :

Malaria is one of the most serious public health problems worldwide. However, there is no effective, FDA approved vaccine available to prevent it. Here we develop a novel virus-like particle (VLP) platform based on alphavirus VLP (i-αVLP), presenting the malaria circumsporozoite protein (CSP) domain. The proprietary i-VLP contains antigen insertions into two different sites of its envelope and has displayed 480 copies of the inserted antigen on each αVLP. The highly symmetrical, dense array of antigens elicits very strong immune responses. Mice and monkeys immunized with the Plasmodium falciparum (Pf) CSP inserted i-VLP produced a high titer of antibodies against CSP. Passive transfer of serum collected from immunized rhesus macaques conferred inhibition of parasite liver stage development in mice exposed to P. berghei expressing a functional Pf CSP. In addition, the ability of anti-CSP antibody induced by i-αVLP-based vaccine was further assessed by using a mouse malaria challenge model. The mice immunized with i-αVLP displaying P. yoelii (Py) CSP also showed protection against a Py sporozoites challenge. These results demonstrate a successful VLP platform accommodating CSP increases immunogenicity, which can provide sterile protection against malaria infection. VLP Therapeutic is launching a clinical development program for the product, VLPM01, highlighted by a planned Phase I/IIa clinical trial in 2016.

Biography :

Wataru Akahata completed his Ph.D. from Graduate School, Kyoto University and postdoctoral studies at the Vaccine Research Center, National Institutes of Health (NIH). He has over 10 years of experience in vaccine development against emerging infectious diseases and received NIH Director’s award for his work in the development of alphavirus vaccines. He is the CEO of VLP Therapeutics, with the mission to develop innovative medical treatments, transform traditional vaccines and targeted antibody therapies in order to address global unmet medical needs.