Journal of Clinical & Experimental Dermatology Research
Open Access

Depression in patients with psoriasis: Effects of biologics

8^th Clinical Dermatology Congress

August 24-25, 2016 Sao Paulo, Brazil

Aymen El Gendy

Zagazig University, Egypt

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Psoriasis is a common chronic immune-mediated inflammatory disorder affecting 2-3% of the population. Psoriasis is associated with a variety of psychological difficulties, including poor self-esteem, social stigmatization, anxiety, depression and suicidal ideation. Psoriasis is associated with substantial impairment of health-related quality of life (HRQOL). Some studies estimated that around one-quarter of patients in dermatology practices have psychiatric disorders. Significantly elevated concentrations of TNF-�?± have been observed in the plasma of patients with psoriasis and in patients with major depression. TNF�?± has been implicated in the pathogenesis of both psoriasis and depression. In humans, administration of TNF�?± blockers such as etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) and IL-12/23 inhibitors have been found to improve depression that accompany psoriasis.

Biography :

Email: aymanelgendy91@yahoo.com