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DDR2 overexpression in oral squamous cell carcinoma is associated | 12246
Virology & Mycology

Virology & Mycology
Open Access

ISSN: 2161-0517

+44 1223 790975

DDR2 overexpression in oral squamous cell carcinoma is associated to lymph node metastasis


Joint Event 10th International Virology Summit & 4th International Conference on Influenza & Zoonotic Diseases

July 02-04, 2018 | Vienna, Austria

Shu Hui Lin

Changhua Christian Hospital, Taiwan

Posters & Accepted Abstracts: Virol Mycol

Abstract :

Background: Oral cancer is the fourth highest incidence of malignancy in males and the seventh highest in the general population of Taiwan. Oral squamous cell carcinoma (OSCC) is the main subtype of oral cancer, which accounts for >95% of all cases of oral cancer. Discoidin domain receptors (DDRs), a collagen receptor tyrosine kinase, play a major role in cancer progression. DDR2 has been suggested as a prognostic marker in several cancer types; however, the correlation between DDR2 expression and clinical outcome of oral cancer patients in Taiwan population has not been investigated.
Material & Methods: In the present study we sought to determine the clinical significance of discoidin domain receptor tyrosine kinase 2 (DDR2) expression in OSCC patients. We examined DDR2 expression in OSCC specimens by immunohistochemistry and then we analyzed the association of DDR2 expression with clinicopathological factors in OSCC.
Result: We divided 254 OSCC cases into two groups based on DDR2 expression levels and compared with several clinicopathological factors and their overall survival. The group with high DDR2 expression had significantly higher frequencies of lymph node metastasis (P=0.0094) and AJCC stage (P=0.0058) compared to the group with low DDR2 expression. Furthermore, the lymph node metastasis oral cancer patients with high DDR2 expression had low survival rate than low DDR2 group (P=0.0458).
Conclusions: Our data indicate that DDR2 is a potent biomarker that can be used as an effective therapeutic target for treating OSCC patients with lymph node metastasis.
Recent Publications:
1. S Y Kao and E Lim (2015) An overview of detection and screening of oral cancer in Taiwan. Chinese Journal of Dental Research 18:7-12.
2. N Ferri, N O Carragher and E W Raines (2004) Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling - Potential implications in atherosclerosis and lymphangioleiomyomatosis. American Journal of Pathology 164:1575-1585.
3. A Shrivastava, C Radziejewski, E Campbell, L Kovac, M McGlynn, T E Ryan, S Davis, M P Goldfarb, D J Glass, G Lemke and G D Yancopoulos (1997) An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Molecular Cell 1(1):25-34.
4. K Zhang, C Corsa, J Prior, D Piwnica Worms and G D Longmore (2013) The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein. Cancer Research 73(8):3939-3939.

Biography :

Shu Hui Lin has her expertise in gene mutation test, cancer diagnosis and cancer research. She is a Leader of Molecular Pathology Department of Changhua Christian Hospital in Taiwan. She has PhD of Institute of Medicine. She is committed to cytological diagnosis and establishment technical of gene mutations test. Her research field focuses on oral squamous cell carcinoma and she hopes that she can find novel therapeutic targets in oral cancer.

E-mail: 74630@cch.org.tw

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