Journal of Clinical and Experimental Ophthalmology
Open Access

Comparison of 5-Fluorouracil and Mitomycin-C in primary treatment of ocular surface squamous neoplasia

18^th Asia Pacific Ophthalmologists Annual Meeting

July 29-30, 2019 | Melbourne, Australia

Akanksha Darda

India

Posters & Accepted Abstracts: Clin Exp Ophthalmol

Abstract :

Aim: To compare efficacy and safety of topical 5-Fluorouracil 1% (5-FU) and Mitomycin C 0.04% (MMC) for Ocular Surface Squamous Neoplasia (OSSN).

Method: This retrospective study included 48 patients of primary OSSN. All were treated with 5-FU or MMC. Primary outcome measure was frequency of complete clinical resolution and recurrence rate. Other outcome measures included duration of treatment and adverse effects.

Results: 22 eyes were treated with 5-FU and 26 with MMC. Complete response was achieved in 86% and 81% eyes with 5-FU and MMC, respectively (P=0.67). Patients were treated with median of three cycles in both groups. Tumor recurrence rate was 7.6% in MMC group while none in 5-FU. The median follow-up after resolution was eight months in 5-FU vs 10 months in MMC. Adverse effects were 18% in 5-FU and 58% in MMC group (P<0.005).

Conclusion: Both 5-FU and MMC seemed to be equally effective for treatment of OSSN. 5-FU can be preferred as it has lower recurrence rate with minimal side effects over MMC.

Biography :

E-mail: akankshadarda@gmail.com