Translational Medicine
Open Access

Cardiovascular pharmacotherapy: Innovation stuck in translation

4^th International Conference on Translational Medicine

October 26-28, 2015 Baltimore, USA

Gerard A Rongen

Radboud University Medical Center, The Netherlands

Posters-Accepted Abstracts: Transl Med

Abstract :

Systematic reviews of animal studies have revealed serious limitations in internal and external validity strongly affecting the reliability of this research. In addition inter-species differences are likely to further limit the predictive value of animal research for the efficacy and tolerability of new drugs in humans. Important changes in the research process are needed to allow efficient translation of preclinical discoveries to the clinic, including improvements in the laboratory and publication practices involving animal research and early incorporation of human proof-of-concept studies to optimize the interpretation of animal data for its predictive value for humans and the design of clinical trials. Illustrated by recent clinical trials in the area of (cardiac) ischemiareperfusion injury performed by this author and his colleagues, the impact of translational problems between animals and humans will be discussed on clinical development of therapeutics.

Biography :

Email: Gerard.Rongen@radboudumc.nl