Journal of Clinical and Experimental Ophthalmology
Open Access

Blocking LINGO-1 reduces degeneration and enhances regeneration of the optic nerve

Global Ophthalmology and Glaucoma Conference

October 13-15, 2016 Kuala Lumpur, Malaysia

Sha Mi

Biogen, USA

Posters & Accepted Abstracts: J Clin Exp Ophthalmol

Abstract :

LINGO-1 is a leucine rich repeat, Ig domain containing, Nogo receptor interactive protein that is selectively expressed in CNS oligodendrocytes and neurons. Its expression is developmentally regulated, as well as up-regulated in CNS diseases and spinal cord injury. LINGO-1 negatively regulates oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration by activating RhoA and inhibiting ATK phosphorylation. Here, we show that anti-LINGO-1 antibody treatment improves optic nerve parallel diffusivity measures on MRI in mice with experimental autoimmune encephalomyelitis (EAE) and reduced optic nerve loss in rat EAE model. Both anti-LINGO-1 antibody therapy and the genetic deletion of LINGO-1 reduced nerve crush-induced axonal degeneration and enhanced axonal regeneration. These data demonstrate that LINGO-1 blockade is associated with axonal protection and regeneration in the injured optic nerve.

Biography :

Email: sha.mi@biogen.com