Chang Yih Duh
Posters-Accepted Abstracts: Virol-mycol
Our long-term research interest is to study the regulation of lytic cycle for human cytomegalovirus (HCMV). By employing our knowledge in HCMV, we aim to develop potential therapeutic marine natural products as anti-HCMV drugs. HCMV, a member of Herpesviridae, is an ubiquitous pathogens among human population. Global prevalence rates are around 60 to 99% in geological distribution. For most of the health people, the HCMV remains life-long latency. Nevertheless, the HCMV is a leading etiological agent causing fetal congenital defects in central nerve system. Moreover, the reactivation of latent HCMV infection can be detrimental or even fatal for those susceptible groups, the organ transplant recipients, and the immunocompromised patients. In the course of our ongoing research focused toward the purification of bioactive metabolites from the organism, seven anti-HCMV marine natural componds were isolated by bioactivity-guided fractionation.