A phylogenetic theory of a disease development: Universality of p | 545
Translational Medicine

Translational Medicine
Open Access

ISSN: 2161-1025

+44 1223 790975

A phylogenetic theory of a disease development: Universality of pathogenesis of �metabolic pandemias� in the light of R. Virchow�s cellular pathology

International Conference on Translational Medicine

September 17-19, 2012 Holiday Inn San Antonio, Texas, USA

Titov V.N

Scientific Tracks Abstracts: Transl Med

Abstract :

Virchow�s cellular pathology indirectly points at structural units between cells and organs in vivo and at universal mechanisms underlying the condition of health or disease. In order to substantiate similarity of pathogenesis of atherosclerosis, diabetes mellitus, metabolic syndrome and obesity we suggest a phylogenetic theory which includes: 1) consideration of physiological and pathological processes in vivo from the viewpoint of biological functions and biological reactions. 2) Phylogenesis of metabolic regulation at the levels of: a) cells (autocrine), b) paracrine cell communities, i.e., structural and functional units of each organ (paracrine), and c) the entire organism. Biological functions are: trophology, homeostasis, endoecology (�purity� of the intercellular medium), adaptation, locomotion, reproduction, and cognition. 3) A three-step successive phylogenesis of biological functions and pathological responses. Methodological approaches in phylogenesis are: a) succession of biological functions and reactions and b) biological subordination where phylogenetically late humoral mediators cannot abolish the effects of phylogenetically early mediators. Incompliance of humoral regulation at different steps of phylogenesis, autocrine, paracrine and the organism levels is the basis for similarity between pathogenesis of all metabolic pandemias, including essential hypertension and insulin resistance syndrome.