Mass Spectrometry & Purification Techniques
Open Access

Diffuse Correlation Spectroscopy

Diffusive correlation spectroscopy (DCS) is an emerging optical technique that measures blood perfusion in deep tissue. In a DCS measurement, temporal changes in the interference pattern of light, which has passed through tissue, are quantified by an autocorrelation function. This autocorrelation function is further parameterized through a non-linear curve fit to a solution to the diffusion equation for coherence transport. The computational load for this non-linear curve fitting is a barrier for the deployment of DCS for clinical use, where real-time results, as well as instrument size and simplicity, are important considerations.