Two-Tailed P-Values Calculation in Permutation-Based Tests: A Warning Against “Asymptotic Bias” in Randomized Clinical Trials

Fernando Pires Hartwig^*

Postgraduate Program in Epidemiology, Department of Social Medicine, Faculty of Medicine, Federal University of Pelotas, Brazil

^*Corresponding Author: Fernando Pires Hartwig, Postgraduate Program in Epidemiology, Department of Social Medicine, Faculty of Medicine, Federal University of Pelotas, Brazil Email: