Elevated Levels of Autoantibodies against ATP2B4 and BMP-1 in Sera of Patients with Atherosclerosis-related Diseases

Ken-ichiro Goto^1,17, Kazuo Sugimoto^1,13, Satoshi Kuwabara¹³, Yo Iwata¹⁴, Takashi Nakayama¹⁵, Jun-ya Harada¹⁵, Yoshio Kobayashi¹⁵, Minoru Takemoto¹⁶, Kazuki Kobayashi¹⁶, Harukiyo Kawamura¹⁶, Ryoichi Ishibashi¹⁶, Ken-ichi Sakurai¹⁶, Masaki Fujimoto¹⁶, Koutaro Yokote¹⁶, Mayumi Muto¹³, Ryutaro Matsumura¹⁸, Takao Sugiyama¹⁹, Haruyuki Hayashi²⁰, Ritsuko Hasegawa²¹, Hideaki Shimada²², Masaaki Ito²², Takashi Kudo²³, Hirofumi Doi²³, Rika Nakamura^1,24, Go Tomiyoshi^1,24, Natsuko Shinmen^1,24, Hideyuki Kuroda²⁴, Kenichiro Kitamura⁷, Toshio Machida², Xiao-Meng Zhang¹, Risa Kimura¹, Hao Wang^1,3, Katsuro Iwase¹, Hiromi Ashino¹, Akiko Taira¹, Emiko Arita¹, Seiichiro Mine^4,5, Mikiko Ohno⁶, Po-Min Chen⁶, Eiichiro Nishi⁶, Takaki Hiwasa^1*, Rika Yamazoe⁸, Hirotaka Takizawa⁹, Koichi Kashiwado¹⁰, Ikuo Kamitsukasa¹¹, Takeshi Wada¹², Akiyo Aotsuka¹², Eiichi Kobayashi⁵, Tomoo Matsutani⁵, Yasuo Iwadate⁵, Naokatsu Saeki⁵, Masahiro Mori¹³ and Akiyuki Uzawa¹³

¹Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chiba, Japan

²Department of Neurosurgery, Chiba Cerebral and Cardiovascular Center, Chiba, Japan

³Department of Anesthesia, The First Affiliated Hospital, Jinan University, Guangdong, PR China

⁴Department of Neurological Surgery, Chiba Prefectural Sawara Hospital, Chiba, Japan

⁵Department of Neurological Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan

⁶Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

⁷Department of Internal Medicine 3, University of Yamanashi School of Medicine, Yamanashi, Japan

⁸Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan

⁹Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, Japan

¹⁰Department of Neurology, Kashiwado Hospital, Chiba, Japan

¹¹Department of Neurology, Chiba Rosai Hospital, Chiba, Japan

¹²Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan

¹³Department of Neurology, Chiba University, Graduate School of Medicine, Chiba, Japan

¹⁴Department of Cardiovascular Medicine, Chiba Cerebral and Cardiovascular Center, Chiba, Japan

¹⁵Department of Cardiovascular Medicine, Chiba University, Graduate School of Medicine, Chiba, Japan

¹⁶Department of Clinical Cell Biology and Medicine, Chiba University, Graduate School of Medicine, Chiba, Japan

¹⁷Department of Orthopedics, National Hospital Organization Chiba-East-Hospital, Chiba, Japan

¹⁸Department of Rheumatology, National Hospital Organization Chiba-East-Hospital, Chiba, Japan

¹⁹Department of Rheumatology, Shimoshizu National Hospital, Chiba, Japan

²⁰Department of Surgery, Sanai Memorial Soga Hospital, Chiba, Japan

²¹Department of Internal Medicine, Sanai Memorial Soga Hospital, Chiba, Japan

²²Department of Surgery, School of Medicine, Toho University, Tokyo, Japan

²³Celish Fd Inc, Chiba, Japan

²⁴Medical Project Division, Research Development Center, Fujikura Kasei Co., Saitama, Japan

^*Corresponding Author: Takaki Hiwasa, Department of Biochemistry and Genetics, Chiba University, Graduate School Of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260- 8670, Japan, Tel: +81 432262541 Email: