Professor, Biochemistry and Molecular Biology
Chinese Academy of Sciences, China
"I graduated from Qingdao University in 1999, majoring in Chemistry, and received Ph.D. degree from the University of Science and Technology of China (USTC) in 2004, with a major of biochemistry and molecular biology. Later on, I had my postdoctoral training from Brandeis University and University of Pennsylvania (UPenn). These professional experiences helped me to build a broad background in biochemistry and molecular biology, with specific training and expertise in structural analysis of macromolecular complexes. Ever since my postdoctoral training at UPenn, I have been intending to deepen my insights into the regulatory nature of immune signaling from the point of view of structure, biochemistry and cell biology. In 2009, I joined Shanghai Institute of Biochemistry and Cell Biology (SIBCB) and started running my own lab. As a principal investigator in SIBCB, I continue to dissect the mechanisms of immune regulations. "
"The immune system is essential for mammals to maintain normal activities of life. Regulation of immune responses is a fundamental aspect of the immune system, because the immune machinery not only undertake the mission of clearing up pathogens from “self (such as cancer cell)” or “non-self (such as virus)”, but also is required to “stay safe”, i.e. to avoid autoimmunity (such as type I diabetes, arthritis). Thus properly regulated signaling is pivotal to the initiation and control of immune responses. Rational design of therapeutic strategies against human diseases related to immune system remains a challenge to date, due to unresolved puzzles of complicated immune regulation. The primary research interest of my group is to establish the structural mechanisms of immune regulations by targeting a variety of important protein/DNA complexes found in relevant transcriptional machinery or signaling pathways. Our major tool is X-ray crystallography combined with nuclear magnetic resonance (NMR), electromicroscopy (EM) and small angle X-ray scattering (SAXS). The derived structural information will be interpreted by using the techniques and assays of biochemistry, molecular biology and cell biology to develop a basis for immune therapy against malicious disease conditions. On top of our goal to understand the fundamental aspects of immune system, we also aim to discover novel target for structure-guided drug design and development. "