Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Xiao-Jian Yao
Associate Professor, Department of Medical Microbiology
University of Manitoba, Canada
Dr. Yao obtained his M.D. and M.Sc. degrees respectively at Suzhou Medical University and National Institute for the Control of Pharma. and Biol. Products in China. Then, he went to Canada and got his Ph.D. degree in 1996 in Dr. E. Cohen’s lab at University of Montreal. Dr. Yao was one of several scientists who first characterized the anti-HIV compound 3TC in vitro.
Since 2004, he established his Human Molecule Laboratory in the University of Manitoba. Now, he is Associate Professor and the Director, Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, University of Manitoba. His lab mainly focuses on HIV and host protein interactions and their functional roles during HIV-1 replication. The optimal goal of his research is to gain better understanding of the mechanism underlying HIV replication and to translate research findings into knowledge for better designing of specific strategies to block HIV infection.
Dr. Yao research interest include Investigation of molecular mechanisms underlying the early stage of HIV replication, especially on HIV-1 integrase/cellular cofactor interactions required for HIV-1 DNA nuclear import, chromatin targeting and integration. Study on the mechanism involved in the combat between HIV-1 Vif and host defenders during HIV-1 infection and development of new antiviral strategies restricting HIV dissemination and inducing broad immune response. Study on the impact of HIV regulatory gene products on HIV replication/pathogenesis and its mother to child transmission.
4) Development of a safe and sensitive avian influenza virus entry system for studying of the impact of H5N1 HA mutations on virus entry in human cells and for screening antiviral agents.