Department of Biochemistry,Microbiology and Molecular Biology
Pennsylvania State University, University Park, PA, USA
Dr. Megha Wal obtained Ph.D. in the lab of Dr. B. Franklin Pugh at The Pennsylvania State University, University Park, where she conducted genome-wide studies to investigate the mechanisms governing nucleosome organization in the budding yeast Saccharomyces cerevisiae. It is well known that the eukaryotic genome is packaged into highly compacted nucleosomal arrays called chromatin. Each nucleosome contains 146-bp DNA, which is tightly wrapped around a histone octamer core. Factors such as DNA sequence, chromatin remodelers (a class of enzymes) and transcription influence nucleosome locations that affects every cellular process that requires access to DNA. Thus, the rules determining nucleosome locations are crucial to understand.
Biochemistry, Genomics, Microbiology, Molecular Biology, Genetics and Cell Biology. Specifically, my expertise is in epigenetics, epigenomics, chromatin biology, transcription biology and gene regulation