Journal of Plant Biochemistry & Physiology
Open Access
ISSN: 2329-9029
ISSN: 2329-9029
Department of Medicine, University Technology MARA, Selangor, Malaysia
Research Article
Identification of Antihypertensive Mechanisms ofFicus deltoidea kunstleri; in Spontaneously Hypertensive Rats Using Metabolomics
Author(s): Harbindar Jeet Singh*, Norasikin Ab Azis, Mohd Saleh Ahmad Kamal, Ahmed Mediani, Renu Agarwal, Zurain Radjeni and Nor Hadiani Ismail
Blood pressure lowering effect of Ficus deltoidea kunstleri (FDK) has been associated with changes in the Renin-Angiotensin-Aldosterone System (RAAS) and endothelial function in Spontaneously Hypertensive Rats (SHR). Whether it also involves other systems is unclear. This study therefore screened for other potential BP lowering mechanisms in FDK-treated SHR based on urine metabolite profile obtained using 1H-NMR spectrometry and multivariate data analysis. Male SHR were administered orally, either 0.5 mL of distilled water (control), or 1000 mg.kg-1 body weight of FDK or 10 mg.kg-1 body weight of losartan once daily for 4 weeks. BP was measured weekly and 24-hr urine was collected using metabolic chambers at the end of the 4th week. Animals were then euthanised and blood was collected for estimation of total anti-oxidant capacity TAC. Kidneys we.. View More»
DOI:
10.35248/2329-9029.21.9.261