Drug Designing: Open Access
Open Access

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia

Publications

• Research Article   
  Design of Effective Molecular Blocker of E Protein Channel as Anti SARS-Cov-2 Virus Drug
  Author(s): Yury N. Vorobjev*
  
  Design of a drug compound that can effectively bind to the E channel and block the diffusion of hydrogen (H+) and K+ ions through channel and inhibit virus life cycle and replication is an important task. A new class of positively charged, +2 e.u., molecules is proposed here to block proton diffusion trough the E channel. Several drug candidates, derivatives of a lead compound (diazabicyclooctane), were proposed and investigated drug binding energy and positions. E protein has in-channe l and out of channelbinding sites of high affinity for suggested molecular blockers. The most promising structure of E channel blocker is suggested... View More»
  DOI: 10.35248/2169-0138.21.10.e186

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