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Design of Effective Molecular Blocker of E Protein Channel as Anti SARS-Cov-2 Virus Drug | Abstract
Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138

+1-947-333-4405

Abstract

Design of Effective Molecular Blocker of E Protein Channel as Anti SARS-Cov-2 Virus Drug

Yury N. Vorobjev*

Design of a drug compound that can effectively bind to the E channel and block the diffusion of hydrogen (H+) and K+ ions through channel and inhibit virus life cycle and replication is an important task. A new class of positively charged, +2 e.u., molecules is proposed here to block proton diffusion trough the E channel. Several drug candidates, derivatives of a lead compound (diazabicyclooctane), were proposed and investigated drug binding energy and positions. E protein has in-channe l and out of channelbinding sites of high affinity for suggested molecular blockers. The most promising structure of E channel blocker is suggested.

Published Date: 2021-06-23; Received Date: 2021-06-02

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