Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Department of Dermatology, Gifu University Graduate School of Medicine, Japan
Research Article
Clinicopathological Differences between Acquired Reactive Perforating Collagenosis and Prurigo Nodularis
Author(s): Miho Kawamura, Madoka Inoue, Kanako Matsuyama, Yoko Mizutani, En Shu, Tatsuhiko Miyazaki and Mariko Seishima*
Background: Acquired reactive perforating collagenosis (ARPC) is a skin disease characterized by multiple itchy
nodules, which is notably similar to the skin eruptions of prurigo nodularis (PN). The aim of this study was to prove
the clinicopathological differences between ARPC and PN.
Methods: We examined 22 patients with ARPC (6 males and 16 females) and 38 patients with PN (27 males and
11 females), diagnosed clinically and histologically. Transepidermal elimination of collagen which is characteristic
histological findings for ARPC was found in all ARPC patients, but not in PN patients even in a serial section.
Clinical findings, laboratory data, histological findings, immunohistochemical results, and efficacy of the therapies
were compared between the two groups.
Results: On evaluation of laborato.. View More»
DOI:
10.35248/2155-9554.21.s8.550