Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Science and Education, Jiangbin Hospital of Guangxi Zhuang, Nanning, China
Research Article
The Causal Role of Immunophenotypes in Colorectal Cancer: A Mendelian Randomization Study
Author(s): Lei Huang and Ying Huang*
Objective: We sought to explore the causal associations between immune cells and Colorectal Cancer (CRC) through the application of Mendelian Randomization (MR).
Methods: The statistical data were gathered from published Genome-Wide Association Studies (GWAS) on immune cells, with genetic variation points being utilized as Instrumental Variables (IVs). For the two-sample Mendelian Randomization (MR) analysis, both Inverse Variance Weighted (IVW) and Bayesian Weighted Mendelian Randomization (BWMR) methods were employed. Additionally, sensitivity analyses were conducted to evaluate the heterogeneity, horizontal pleiotropy and robustness of the findings.
Results: The IVW analysis revealed that 37 immunophenotypes have a causal link to colorectal cancer. Additionally, the BWMR method identified 4 immune phenotypes wit.. View More»