Department of Immunology, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center (Affiliated to Tel-Aviv University), Tel-Hashomer 5265601, Tel Aviv, Israel
Vaccines and Optic Neuritis: Consequence or Coincidence?
Author(s): Justyna Roszkiewicz and Yehuda Shoenfeld*
A mosaic of various inflammatory diseases associated with the administration of vaccines has been reported in the literature. Optic Neuritis (ON), a primary inflammation of the optic nerve, serves as an prominent piece of it, presenting the features of autoimmune phenomena including Treg/Th17 cell imbalance and the abundance of proinflammatory cytokines. A PubMed search revealed 48 cases of vaccination-related ON, from which 32 were reports as isolated ON, 9 occurred as the first symptom of neuromyelitis optica spectrum diseases (NMOSD) and 6 were inscribed in clinical course of Acute Disseminated Encephalomyelitis (ADEM). In Vaccine Adverse Effects Reporting System (VAERS) 537 reports of ON were identified, the vast majority of them was isolated (n=284), followed by ON preceding multiple sclerosis (n=99), ADEM (n=30) and NMOSD (n=20). Influenza vaccine was the leading cause of isolat.. Read More»