Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medial Sciences, Beijing, 100730, China

Publications

• Short Communication   
  Mesothelin: An Immunotherapy Target
  Author(s): Wu Wiu De*
  
  CAR-T cell therapy targeting CD19 has achieved a pace in treatment of B cell malignancies, while different strong malignancies are as yet headstrong for absence of appropriate objective. Lately, an enormous number of studies have looked to discover reasonable focuses with low "on target, off tumor" concern for the treatment of strong/solid tumors. Mesothelin (MSLN), a tumor-associated antigen extensively overexpressed on different dangerous tumor cells, while its expression is the most part restricted to typical mesothelial cells, which is an appealing possibility for targeted treatment. Strategies focusing on MSLN, including antibody-based drugs, immunizations/vaccination and CAR-T treatments, have been evaluated in countless preclinical examinations and clinical trials. Specifically, the improvement of CAR-T treatment has shown incredible guarantee as .. View More»
  DOI: 10.35248/jcclm.21.4.184

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