Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hun, Collaborative Innovation Center for New Molecular Drug Research, University of South China, Hengyang, P.R. China
Mini Review
HIV Associated Eye Diseases: Existing Cognitive and Possible Mechanisms
Author(s): Tie Zhao*
The Human Immunodeficiency Virus-1 (HIV-1) envelope protein gp120 is the major contributor to the
pathogenesis of retinopathy and uveitis in HIV-1-related eye diseases. Disruption of the structure and function of
the Blood-Retina Barrier (BRB) is the major contributor of HIV-1-related eye diseases and the molecular
mechanism remains unknown. Our mini review revealed that retinopathy and uveitis are required for gp120-
induced inflammation and epigenetic changes and suggest that gp120 regulate tight junction protein... View More»
DOI:
10.35248/2155-9570.20.11.828