ISSN: 2167-0870
+44 1478 350008
Tokai University Hospital, Isehara-shi, Kanagawa, Japan
Mini Review
Intestinal Dysbiosis and Probiotics in COVID-19
Author(s): Yasunari Kageyama, Tetsu Akiyama and Tsutomu Nakamura*
The COVID-19 pandemic has been an emerging threat to global public health. Several lines of evidence suggest that the causative virus SARS-CoV-2 infects the human intestinal epithelial cells as well as airway epithelial cells, suggesting that the enteric infection of SARS-CoV-2 has destructive effects on the intestinal microbiota and subsequently airway physiology and immunity through the gut-lung axis. Despite the important roles of the gut-lung axis in the antiviral immunity, only limited information is currently available concerning COVID-19-specific changes in the gut microbiome. This review summarizes recent knowledge of intestinal dysbiosis associated with COVID-19 patients and its potential contribution to the respiratory symptoms through the gut-lung axis. We also discuss the possibility of prophylactic and therapeutic use of probiotics in COVID-19, including our ongoing trial.. View More»
DOI:
10.35248/2167-0870.20.10.421