Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Vitreoretinal Sciences, Rajan Eye Care Hospital, Chennai, Tamil Nadu, India
Research Article
Brolucizumab in Age-Related Macular Neovascularization (Brain Study): Efficacy, Optical Coherence Tomography Biomarkers and Safety Profile over 18 Months
Author(s): Supriya Dabir*, Arthi Mohankumar, Manoj Khatri and Mohan Rajan
Background: Brolucizumab is a new anti-Vascular Endothelial Growth Factor (anti-VEGF) in treatment of neovascular
Age-related Macular Degeneration (nAMD) and Idiopathic Polypoidal Choroidal Vasculopathy (IPCV).
Materials and methods: A retrospective, consecutive, interventional studies from a tertiary eye hospital, where
treatment naive and treatment switch patients were included. They underwent intravitreal injection Brolucizumab.
Decision to reinject was made on presence of fluid on Spectral Domain Optical Coherence Tomography (SD OCT)
or worsening of vision at follow-up. Outcome measures were change in Best Corrected Visual Acuity (BCVA), Central
Subfield Thickness (CST) and changes in fluid (sub-retinal/intra-retinal/sub retinal pigment epithelium fluid) levels,
Optical Coherence Tomography (OCT) biomarkers and safety ana.. View More»
DOI:
10.35248/2155-9570.23.14.954