Translational Medicine
Open Access

Department of Pediatrics, PLA General Hospital, China

Publications

• Short Communication   
  Translational Medicine 2015: Survivin siRNA nano particles are capable of inhibiting cancer cell growth both in vitro and in vivo - Suoqin Tang - PLA General Hospital
  Author(s): Suoqin Tang*
  
  Since the stability of siRNA molecules inside the blood and efficiency of siRNA distribution into target organs or tissues subsequent systemic management are the main issues that limit requests of siRNA in human patients, we attempt to explore if siRNA liposome entrapment works within the development of novel therapeutics. Our study aims to guage the therapeutic effect of survivin siRNA nano particles, on cancer of the liver, carcinoma and cervical cancer both in vitro and in vivo. First, sequences of survive in siRNA we designed had been screened for his or her efficacy, and therefore the best one was chosen for subsequent study. Second, we've tested the biological effect of survivin siRNA nanoparticles on neoplastic cell lines in vitro, and resulted that, the survivin mRNA and its protein expression was significantly inhibited in MHCC-97H cells, HeLa cells and LoVo cells, also p.. View More»
  DOI: 10.35248/2161-1025.20.10.213

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