Journal of Clinical Trials
Open Access

Department of Medical Science, Boston University School of Medicine, Boston, United States

Publications

• Research Article   
  Patient- Reported Reasons for a COVID-19 Therapeutics Clinical Trial: Findings from a Multi-Center Investigation
  Author(s): Samira Reyes Dassum*, Ryan Ferguson, Patricia Woods, Maura Flynn, Karen Visnaw, Erika Holmberg, Sara Schiller, Colleen Shannon, Mary Brophy, Paul Monach, Sarah Leatherman and Westyn Branch-Elliman
  
  Background: Early in the COVID-19 pandemic, no evidence proven therapeutics were available, and thus participation in a clinical trial was often the only way to access experimental therapeutic options. In the US, participation in medical research is low, and patient stated factors driving non-enrollment decisions are poorly characterized. Thus, the aim of this study was to identify patient and legally-authorized representative reported reasons for declining enrollment in a COVID-19 therapeutics trial identify potential strategies for addressing barriers in future investigations. Methods: As part of a pragmatic randomized trial during the period from 4/10/20-2/3/21, SARS-CoV-2 positive inpatients with moderate to severe disease were screened for eligibility. If eligible patients declined to participate, they were asked an ope.. View More»
  DOI: 10.35248/2167-0870.22.12.508

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