Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

+44 1223 790975

Serdar Bilici

Kahramankazan Hamdi Eris State Hospital, Ankara, Turkey

  • Research Article   
    Thiol and Glutathione Homeostasis Parameters as Plasma Biomarkers of Oxidative Stress in Age-Related Macular Degeneration
    Author(s): Serdar Bilici*, Mehmed Ugur Isik and Murat Alisik

    Purpose: To determine extracellular thiol homeostasis and intracellular glutathione homeostasis as a plasma biomarker for oxidative stress and to compare these parameters in non-exudative/exudative AMD patients and healthy individuals. Method: 30 non-exudative AMD, 28 exudative AMD, and 36 age-matched healthy control subjects enrolled to the study. Extracellular total thiol, native thiol, disulphide amounts and intracellular oxidized/reduced glutathione levels of subjects were determined, and disulphide/thiol and oxidized/reduced glutathione percent ratios were calculated. Results: In comparison with the control group both non-exudative and exudative AMD patients had higher plasma disulfide levels (20.5(4.8) vs. 4(3.1), p<0.001 and 22.5(7.5) vs. 15.4(3.1), p<0.001; respectively) and higher disulphide/thiol (6.. View More»

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