Drug Designing: Open Access
Open Access

Department of Pharmaceutical Chemistry, Benghazi University, Benghazi, Libya

Biography

Dr. is currently working at Pharmacy Department. Dr. is research interests includes Pharmacy in Medication Adherence. Dr. serving as an editorial member and reviewer of several international reputed journals. Dr. has successfully completed his Administrative responsibilities. Dr. has authored of many research articles/books related to Medicine.

Publications

• Research Article   
  Computational, Pharmacological Evaluation and Comparative Similarity against Chloroquine for Some New Designed Hybridized Molecules and their Potential Use as Antiviral against COVID-19 and Malaria
  Author(s): Adel M Najar*, Ruwida MK Omar and Eman Bobtaina
  
  Starting from the concept of "similar molecules exert similar biological activities" to modify structures of biologically active molecules or readily available drugs to improve their therapeutic activity or reduce side effects. Four designed 7- Chloroqunioline-N-Heterocyclic molecules that are derived from parent compound chloroquine (which recently has attracted wide international attention due to its potential activity against COVID-19) were investigated regarding QSAR and some electronic parameters compared to the original drug. Their chemical properties, biochemical properties, and physio-chemical properties were evaluated using computational chemistry. The method used for calculations was semi-empirical-geometry optimization-PM3. Single crystal X-ray crystallography data of Chloroquine and calculated data have been done using the same parameters. Su.. View More»
  DOI: 10.35248/2169-0138.20.9.163

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