Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+44 1223 790975
ISSN: 2169-0138
+44 1223 790975
Department of Chemistry, Benghazi University, Benghazi, Libya
Research Article
Computational, Pharmacological Evaluation and Comparative Similarity against
Chloroquine for Some New Designed Hybridized Molecules and their Potential
Use as Antiviral against COVID-19 and Malaria
Author(s): Adel M Najar*, Ruwida MK Omar and Eman Bobtaina
Starting from the concept of "similar molecules exert similar biological activities" to modify structures of biologically
active molecules or readily available drugs to improve their therapeutic activity or reduce side effects. Four designed 7-
Chloroqunioline-N-Heterocyclic molecules that are derived from parent compound chloroquine (which recently has
attracted wide international attention due to its potential activity against COVID-19) were investigated regarding
QSAR and some electronic parameters compared to the original drug. Their chemical properties, biochemical
properties, and physio-chemical properties were evaluated using computational chemistry. The method used for
calculations was semi-empirical-geometry optimization-PM3. Single crystal X-ray crystallography data of Chloroquine
and calculated data have been done using the same parameters. Su.. View More»
DOI:
10.35248/2169-0138.20.9.163