Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
University of Nigeria, Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu State, Nigeria
Review Article
The JAK-STAT Signaling Pathway: A Novel Therapeutic Target for Unexplained Recurrent Implantation Failures
Author(s): Alphonsus Ogbonna Ogbuabor*, Peter Uwadiegwu Achukwu, Daniel Chukwuemeka Ogbuabor, Silas Anayo Ufelle and Rapheal Chinweike Okolo
Unexplained recurrent implantation failure has become a public health problem especially in the context of a high
cost, demand for assisted reproductive therapy and multiple therapy failures. It is attributed to the failure of
immunological tolerance between the transferred embryo and the endometrium during assisted reproductive therapy
cycles. Cytokines are surrogate mediators of immunological tolerance mechanisms. Since the synergistic interaction
between individual cytokines is dynamic, perturbations in the cytokine crosstalk during embryo implantation is
considered a major etiology for unexplained recurrent implantation failures. Genome Wide Association Studies
suggests that most cytokines initiate their actions through receptor interactions that activate the JAK-STAT signaling
pathways. Aberrations in the JAK-STAT signaling pathways have as well been shown to.. View More»
DOI:
10.35248/2155-9899.20.11.587