Advances in Pediatric Research
Open Access
ISSN: 2385-4529
ISSN: 2385-4529
Department of Neonatology, NMC Specialty Hospital, Dubai, United Arab Emirates
Research Article
Efficacy of Inhaled Nitric Oxide and Intragastric Sildenafil in Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) on High Frequency Oscillatory Ventilation (HFOV)
Author(s): Rajiv Parapurath* and Madan Samuel
Background: Optimizing management of Persistent Pulmonary Hypertension of Newborn (PPHN) continues
following availability of oral and intravenous Phosphodiesterase-V inhibitors. Study queried whether High Frequency
Oscillatory Ventilation (HFOV) coupled with pulmonary vasodilators improves outcomes in neonates with severe-
PPHN.
Objective: To prospectively evaluate efficacy of inhaled Nitric Oxide (iNO) and intra Gastric Sildenafil (iGS) in
neonates with severe-PPHN on HFOV and exogenous surfactant.
Methods: Eighty-four consecutive neonates with severe-PPHN on HFOV and exogenous surfactant were treated
with iNO (n=40) or iGS (n=44). Primary (28 days) outcomes analysed were adverse events, failure rate and mortality.
Secondary (24 months) outcomes were neurological impairment, sensorineural deafness an.. View More»
DOI:
10.35248/2385-4529.23.10.068