Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Immunopathology, Shanghai Jiao Tong University, Minhang, China
Case Report
Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Author(s): Qing Chen, Wang Liu and Zhongbin Zhoa*
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the
clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CTLA-4
checkpoint inhibitor, and an Indoleamine 2,3-Dioxygenase (IDO)-silenced Dendritic Cell (DC) vaccine. The
treatment approach aimed to enhance antitumour immunity by blocking immune checkpoints and activating
dendritic cells. The patient demonstrated a significant clinical response, indicating the diversification and
potentiation of the antitumour effects. This case underscores the potential of combined immunotherapeutic
strategies in achieving durable and robust antitumour effects... View More»
DOI:
10.35248/2155-9899.23.14.688