International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
ISSN: 2329-9096
Department of Pharmacology, UCL School of Pharmacy, London, UK
Research Article
Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3d Co-Culture Model of Neurodegeneration
Author(s): Poppy O Smith, Ryan P Trueman, Rebecca Powell, Holly Gregory, James B Phillips, Patrizia Bohnhorst and Melissa LD Rayner*
Background: Peripheral neuropathy is a common neurological disease with numerous causes. Diabetes remains
one of the most common causes with 50% of diabetic patients affected at some stage of disease progression. To
identify and screen potential small molecule therapeutics effectively, sophisticated pre-clinical models are
needed. In-vitro models provide a useful way to explore the fundamental effects of potential therapies and aid the
understanding of their mechanistic properties.
Methods: Within this study we have developed an in-vitro model of neurodegeneration, which was then used
to screen the effect of the B vitamins (B1, B6 and B12) on neurite regeneration.
Findings: Our results indicate vitamins B1, B6 and B12 in combination or individually improve neurite regeneration.. View More»
DOI:
10.35248/2329-9096.23.11.667