Journal of Clinical Trials
Open Access

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

Publications

• Commentry   
  Roles of Complement and Extracellular Histones in Infectious Sepsis
  Author(s): Peter A Ward*
  
  In North America, infectious sepsis is associated with bacteria, fungi, protozoa and viruses. It has been well established that age is an important factor. Septic patients of 60 years of age, or greater, are much more susceptible to lethality as compared to patients whose age is around 40 years of age. Recently, there is also evidence that sepsis associated with non-penetrating trauma, drug toxicity of liver, or hemorrhagic shock are associated with similar responses developing in infectious sepsis. Following onset of sepsis (infectious or non-infectious), during the first 2-3 days there is a “cytokine storm,” also involving proinflammatorychemokines.Typically, IL-1β, IL-6, TNF and IL-17A and F rapidly rise in plasma. After day 3-4, this inflammatory cascade related to the innate immune system (involving neutrophils, macrophages and an array of pr.. View More»
  DOI: 10.35248/2167-0870.20.10.418

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