Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
+44 1223 790975
ISSN: 2165-8056
+44 1223 790975
Department of Medicine, Centre for Proteomics Research, University of Malaya, Kuala Lumpur, Malaysia
Research Article
Ganoderma lucidum Modulates Neuronal Distorted Cytoskeletal Proteomics and Protein-Protein Interaction in Alzheimer's Disease Model Animals
Author(s): Mohammad Azizur Rahman*, Shahdat Hossain, Noorlidah Abdullah and Norhaniza Aminudin
Background: Alzheimer’s disease (AD) is the leading neurodegenerative disorder affecting memory, learning and
behavior. Altered expression of proteins involved in neuronal structure and function is a recent observation of AD
pathogenesis. Modulation of altered protein expression seems promising in AD therapeutics. In the present
experiment, AD ameliorating effect of medicinal mushroom Ganoderma lucidum (GL) had been evaluated through its
effect on neuronal cytoskeletal structure and function related protein expression pattern in AD model rats.
Methods: Wistar male rats (120 ± 5 gm) were divided into three groups: control rat (CR), Alzheimer’s Disease Model
Rat (ADMR) and G. lucidum Hot Water Extract (GHWE) fed ADMR, each group containing 15 rats. AD model rats
were prepared by infusing Aβ1-4.. View More»
DOI:
10.35248/2165-8056.20.S1.002