Journal of Clinical Trials
Open Access

Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

Publications

• Research Article   
  Predictors of Treatment Adherence in a Randomized Clinical Trial of Digital Therapeutics with Pharmacology for Alcohol Use Disorder (AUD)
  Author(s): Morris D. Bell*, Yarani Gonzalez, Brian Pittman and Gihyun Yoon
  
  Background/Aims: Non-adherence is a significant issue in clinical trials of new therapeutics; and Alcohol Use Disorder (AUD) studies are particularly vulnerable to discontinuation. Moreover, clinical trials involving behavioral intervention over time may be even more difficult to complete. Digital therapeutics make participation in treatment much more accessible and may therefore reduce one of the barriers to study participation. This study aims to investigate predictors of treatment adherence in a clinical trial that collected data over 13 weeks involving a digital therapeutic Cognitive Remediation Therapy (CRT) and donepezil for patients with AUD, focusing on (1) CRT adherence (total hours completed); (2) medication adherence (pill count) and (3) total adherence that combines 1 and 2. Methods: Baseline data including demographics, illness .. View More»
  DOI: 10.35248/2167-0870.25.15.597

  Abstract HTML PDF