Journal of Clinical and Cellular Immunology
Open Access

Institute of Molecular Biology, University of Nyala, Nyala, Sudan

Publications

• Research Article   
  Prenatal Corticosterone Exposure Alters Glucocorticoid Metabolic Enzyme Eene mRNA Associated with Increased Aggressive Behaviors and Tonic Immobility in Chicken
  Author(s): Abdelkareem A Ahmed*, Mohammed Elmujtba Adam Essa, Adriano Mollica, Azzurra Stefanucci, Gokhan Zengin, Hussain Ahmed and Ayman Sati Sati Mohamed
  
  Exposure to excess Glucocorticoids (GCs) during embryonic development influences offspring physiology and behaviors and induces change in Hypothalamic-Pituitary-Adrenal (HPA) axis genes expression and serotonergic system in mammals. Whether prenatal corticosterone (CORT) exposure induces similar effects in avian species remains unclear. In the present study, we injected low (0.2 μg) and high (1 μg) doses of CORT in ovo before incubation and detected changes in aggressive behavior, Tonic Immobility (TI), HPA axis and 5-hydroxytryptamine (serotonin) (5-HT) system gene expression on post hatch chickens of different ages. High dose of CORT significantly (P<0.05) suppressed growth rate, increased the frequency of aggressive behaviors, which was associated with elevated plasma CORT concentration. Likewise, in ovo injection of CORT significantl.. Read More»
  DOI: 10.35248/2155-9899.20.11.604

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