Journal of Cell Signaling

Journal of Cell Signaling
Open Access

ISSN: 2576-1471

Melo AC

The Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA

  • Research Article   
    The Microbiome Product Urolithin A Abrogates the TGF-β-EGFR-PAI-1 Pathway in NRK-52e Renal Epithelial Cells
    Author(s): Chappell MC*, Pirro NT, Melo AC, Tallant EN and Gallagher PE

    Ellagitanins are natural and complex polyphenolic compounds enriched in foods and commercial supplements. They are initially hydrolyzed to ellagic acid and further metabolized to urolithins by the gut microbiome. Ellagitanins are among a number of endogenous compounds found in fruits, nuts and vegetables that comprise a cardio protective diet for humans; however, biotransformation to urolithins may underlie their protective effects. Chronic treatment with urolithin A conveys anti-fibrotic and anti-inflammatory actions in experimental models of brain, cardiac, and kidney injury. Since the cellular actions and signaling events of urolithin A are undefined in renal cells, we assessed the influence of urolithin A on the TGF-β-PAI-1 pathway in NRK-52e cells, a well-characterized model of the proximal tubule epithelium and TGF-β induced signaling. TGF-β stimulated PAI-1 relea.. Read More»
    DOI: 10.35248/2576-1471.20.5.204

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