Journal of Leukemia
Open Access

Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland

Publications

• Research Article   
  Primary and Secondary Central Nervous System Involvement in Acute Myeloid Leukemia
  Author(s): El�?¼bieta Patkowska*, Andrzej Szczepaniak, Marta Barańska, Maciej Kaźmierczak, Monika Paluszewska, Wiesław Wiktor Jędrzejczak, Renata Guzicka-Kazimierczak, Wanda Knopińska-Posłuszny, Olga Grzybowska-Izydorczyk, Agnieszka Pluta, Jarosław Piszcz, Izabela Dereń-Wagemann, Ewa Lech-Marańda and Joanna Góra-Tybor
  
  Introduction: Central Nervous System involvement (CNSi) in patients with Acute Myeloid Leukemia (AML) rarely occurs. It is not well characterized clinically and lacks standardized treatments. Patients and methods: A retrospective analysis of 77 consecutive AML patients with primary and secondary CNSi during 2004-2016 was performed in eight Polish haematological centres. Results: 77 patients (38 with primary CNSi-AML) were included. Median age was 44 years in both groups. Elevated lactate dehydrogenase activity was found in the majority of subjects. Patients in primary CNSi-AML group more often had myelomonocytic and monoblastic AML subtypes (68.4%) compared to secondary CNSi AML (43.5%) (p=0.039). There were no differences between both groups in the number of leukocytes or the proportion of blast cel.. View More»
  DOI: 10.35248/2329-6917.19.7.257

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