Journal of Clinical and Cellular Immunology
Open Access

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada

Publications

• Review Article   
  Pharmacological Inhibition of cAMP Signaling is an Attractive Therapeutic Strategy for Management of Chronic Inflammatory and Autoimmune Diseases
  Author(s): Issaka Yougbare*
  
  Systemic Lupus Erythematosus (SLE) evolves into progressive and chronic inflammation of multiple joints and organs. No specific treatment exists for SLE which presents a diverse clinical polymorphism with unclear pathogenicity. Women at their pre-menopausal age are the most affected and early studies have reported the implication of estrogen in T cell abnormalities. Alteration of cAMP signaling in immune cells and target organs is emerging as cellular mechanism governing SLE disease progression. We recently reported that activity and expressions of PDE4, the major cAMP hydrolyzing enzyme were deregulated in kidney of lupus prone mice. Therefore, PDE4 inhibitors may exert anti-inflammatory effects on several immunocompetent cells including T and B lymphocytes, and macrophages. Several PDE4 inhibitors achieved good therapeutic values as potent anti-inflammatory comp.. View More»
  DOI: 10.35248/2155-9899.21.12.613

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