Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Department of Ophthalmology, Affiliated Hospital of Yunnan University, Yunnan Eye Institute, Kunming, Yunnan, China

Publications

• Research Article   
  TNFSF15 Inhibits Progression of Diabetic Retinopathy by Blocking Pyroptosis via Interacting with GSDME
  Author(s): Hongkun Zhao, Yating Dai, Yunqin Li, Juanjuan Li* and Hua Li*
  
  Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology. This study explored the role of Gasdermin E (GSDME)-mediated pyroptosis and its regulation by TNFSF15 in diabetic retinopathy. We found GSDME was upregulated in the progression of diabetic retinopathy. High glucose promoted GSDME-induced pyroptosis in retinal endothelial cells and retinal pigment epithelial cells, attributable to activation of caspase-3 which cleaves GSDME to generate the pyroptosis-executing N-terminal fragment. TNFSF15 was identified as a binding partner and inhibitor of GSDME-mediated pyroptosis. TNFSF15 expression was increased by high glucose but suppressed by the caspase-3 activator Raptinal. Moreover, TNFSF15 protein inhibited high glucose an.. View More»
  DOI: 10.35248/2736-6588.24.7.282

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