ISSN: 2161-0517
+44 1223 790975
Biochemistry Data Analyst, GDS Applied Mathematics BV, Den Haag, Netherlands
Review
Occurrence of the Slippery Sequence UUUAAAC in the RNA Genome 2 that generates the ORF1ab Protein of SARS-CoV-2
Author(s): Geurdes H*
In the present brief report we look into the slippery sequence TTTAAAC (in cDNA format) of the ORF1ab protein
of SARS-CoV-2. We found a number of TTTAAAC sequences where only one is actively producing a shift-1. There
are three other sequences exactly positioned in the read-through of mRNA as the aforementioned. They do not
produce a-1 frameshift. There is one position where in addition a pseudoknot occurs but no frameshift. We ask if it
is possible to enforce or prevent shifts in TTTAAAC to destroy the ORF1ab derived proteins such as RNA-dependent
RNA polymerase and/or 2’-O-ribose methyltransferase. Finally an mRNA polymer repressor of the one single
effective frameshift is proposed for further research into a medicinal treatment. Perhaps that there are specific protein
repressors... View More»
DOI:
10.35248/2161-0517.20.9.198