Virology & Mycology
Open Access

Biochemistry Data Analyst, GDS Applied Mathematics BV, Den Haag, Netherlands

Publications

• Perspective   
  Histamine Antagonists to Temper the Cytokine Overproduction in Gastrointestinal Cells Infected by SARS-CoV-2
  Author(s): Geurdes H*
  
  The premise regarding COVID-19 disease is that it is a spectrum which begins with infection with viral SARS-CoV-2 exposure via airborne or oral virus particles. The individual response to it depends on many factors including comorbid conditions. An important aspect of SARS-CoV-2 virus infection is the cytokine storm that develops after the infection. The immunochemical chaos created in this cytokine storm is to the benefit of the virus. In this metaanalysis the authors explore ways to let the cytokine storm die down by looking into the role of histamine. Histamine is a metabolic product of the essential amino acid histidine. Histamine has 4 known receptors: H1, H2, H3 and H4. The immuno globulines IgG and IgM are indicative for a COVID-19 infection. This immune response is related to inflammation. Inflammation, in turn, runs mainly via histamine after e.g. virus i.. View More»
  DOI: 10.35248/2161-0517.20.09.189

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