Journal of Clinical Trials
Open Access

Radiant Research, R&D Division, Bangalore, India

Publications

• Research Article   
  Phosphatidylserine Matrix Enhances Lutein/Zeaxanthin Exposure versus Phosphatidylcholine, Liposome, and MCT Oil in Rats: A 24?Hour Pharmacokinetic Study
  Author(s): S. Mehkri, K.G. Dinesh, G. Ashok and Krathish Bopanna*
  
  Background: Lutein and Zeaxanthin (LZ) support macular function, but oral absorption is limited by intestinal solubilization and uptake; phospholipid environments may improve micellization and enterocyte transport. Objective: To evaluate whether an anionic Phosphatidylserine (PS) matrix enhances single-dose LZ exposure compared to Phosphatidylcholine (PC), a reconstituted liposomal powder, and Medium-Chain Triglyceride (MCT) oil in rats. Methods: Male Sprague-Dawley rats (n=6 per group) received oral gavage of dose-matched lutein (10 mg/kg) in four matrices (MCT, MCT+PC, MCT+PS, liposome); serial plasma samples (0-24 h) were analysed using validated LC-MS/MS (calibration 5-250 ng/mL). Noncompartmental pharmacokinetics were calculated; group differences in Cmax and AUC?–t were evaluated via one-way ANOVA with .. View More»
  DOI: 10.35248/2167-0870.25.15.607

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