Journal of Proteomics & Bioinformatics
Open Access

Radiation Oncology Branch, National Cancer Institute, 10 Center Drive, Building 10, CRC, Bethesda, Maryland, USA

Publications

• Research Article   
  The Quiescent Metabolic Phenotype of Glioma Stem Cells
  Author(s): Elizabeth I Spehalski, Jennifer A Lee, Cord Peters, Philip Tofilon and Kevin Camphausen*
  
  Introduction: Glioblastoma (GBM) is the most common primary malignant brain tumor in humans and, even with aggressive treatment that includes surgical resection, radiation (IR), and chemotherapy administration, prognosis is poor due to tumor recurrence. There is evidence that within GBMs a small number of glioma stem-like cells (GSLCs) exist, which are thought to be therapy resistant and are thus capable of repopulating a tumor after treatment. Like most cancers, GBMs largely employ aerobic glycolysis to create ATP, a phenomenon known as the Warburg Effect. There is no consensus on the metabolic characteristics of cancer stem cells. GSLCs have been shown to rely more heavily on oxidative phosphorylation, but there is also evidence that cancer stem cells can adapt their metabolism by fluctuating between energy pathways or acquiring intermediate metabolic phenotypes. We.. View More»
  DOI: 10.35248/0974-276X.19.12.502

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