Mycobacterial Diseases
Open Access
ISSN: 2161-1068
ISSN: 2161-1068
Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Research Article
miR-20a-5p, miR-29a, miR-let7e, and miR-155 Serum Exosomal microRNAs Analyses as Potential Biomarkers in Pulmonary tuberculosis and Non-tuberculosis
Author(s): Alireza Javadi*, Masoud Shamaei, Payam Tabarsi, Elaheh Ainy and Bahram Kazemi*
Background: Mycobacteria could invade the host’s immune system to survive and persist in the host through different mechanisms such as the expression modulation of microRNAs (miRNAs). microRNA is a small, noncoding oligonucleotide that regulates gene expression and transcription. miRNAs' differential expressions in disease phenomena can serve as biomarkers. The expression level of serum-derived exosomal miRNAs from mycobacteria patients could result to enhance monocyte cell apoptosis. This study tries to evaluate four serumderived exosomal miRNAs as a potential mycobacterial biomarker.
Methods: Serum-derived exosomes were purified from serum samples of 55 patients with pulmonary tuberculosis or non-tuberculosis and 30 healthy controls. The expression level of Hsa-miR-20a-5p, Hsa-miR-29a, Hsa-miRlet7e, and Hsa-miR-155 was evaluated .. View More»
DOI:
10.35248/2161-1068,.23.13.311