Orthopedic & Muscular System: Current Research
Open Access
ISSN: 2161-0533
ISSN: 2161-0533
Department of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Athens, Greece
Research Article
The Effect of Tahini and Sesame Perisperm Extract on the Rodent Post-Menopausal Osteoporosis Model
Author(s): Spyridon Zoitsis*, Pavlos Lelovas, Anna Aikaterini Neri, Dimitris Galanis, Dimitris Michailidis, Sofia Mitakou, Ermioni D Pasiou, Stavros K Kourkoulis, Angeliki Eirini Pepe, Panagiotis Papadopoulos, Antonios Galanos, Efstathios Chronopoulos, Georgios Sapkas and Ismene A Dontas
Objective: This study aimed to examine the impact of sesame (tahini and sesame perisperm) on the postmenopausal bone mineral density ovariectomized rat model, as a potential agent for managing postmenopausal osteoporosis, either as a dietary supplement or as a substitute for hormone replacement therapy, without the severe side effects of other treatments.
Methods: Forty female, ten-month-old, Wistar rats were divided into control (n=10), Ovariectomized (OVX, n=10), Ovariectomized-Plus-Tahini (OVX+T, n=10) and Ovariectomized-Plus-Sesame Perisperm Extract (OVX+SPE, n=10), groups. Total and proximal tibial Bone Mineral Density (BMD) were measured by Dual-Energy X-ray Absorptiometry (DEXA) at baseline, 3 and 6 months afterward. Femurs were subjected to a Three-Point Bending Test (3PBT) at the end of the study, and the uterine weight and its rati.. View More»
DOI:
10.35248/2161-0533.23.12.371