Orthopedic & Muscular System: Current Research
Open Access

Abstract

The Effect of Tahini and Sesame Perisperm Extract on the Rodent Post-Menopausal Osteoporosis Model

Spyridon Zoitsis*, Pavlos Lelovas, Anna Aikaterini Neri, Dimitris Galanis, Dimitris Michailidis, Sofia Mitakou, Ermioni D Pasiou, Stavros K Kourkoulis, Angeliki Eirini Pepe, Panagiotis Papadopoulos, Antonios Galanos, Efstathios Chronopoulos, Georgios Sapkas and Ismene A Dontas

Objective: This study aimed to examine the impact of sesame (tahini and sesame perisperm) on the postmenopausal bone mineral density ovariectomized rat model, as a potential agent for managing postmenopausal osteoporosis, either as a dietary supplement or as a substitute for hormone replacement therapy, without the severe side effects of other treatments.

Methods: Forty female, ten-month-old, Wistar rats were divided into control (n=10), Ovariectomized (OVX, n=10), Ovariectomized-Plus-Tahini (OVX+T, n=10) and Ovariectomized-Plus-Sesame Perisperm Extract (OVX+SPE, n=10), groups. Total and proximal tibial Bone Mineral Density (BMD) were measured by Dual-Energy X-ray Absorptiometry (DEXA) at baseline, 3 and 6 months afterward. Femurs were subjected to a Three-Point Bending Test (3PBT) at the end of the study, and the uterine weight and its ratio to body weight were examined.

Results: Both total and proximal tibial BMD values and percentage changes from the baseline of the OVX+Τ and OVX+SPE groups, were statistically significantly higher than those of the OVX group at all times. In 3PBT, the right femurs of the OVX+SPE group presented statistically significant increased value compared to the OVX group, for the indices Mises stress and bending stress, and the left femurs of the OVX+T group showed statistically decreased value for the torsional stress index.

Conclusion: Sesame tahini and perisperm extract improved postmenopausal tibial BMD loss. Ameliorative changes in biomechanical strength were also noted during the three-point bending test. Thus, sesame extract and tahini could consist important factors in the management of osteoporosis. Further research on the effects of sesame by-products in postmenopausal osteoporosis is imperative.

Published Date: 2023-11-27; Received Date: 2023-10-25