Journal of Clinical Trials
Open Access

Oncology Unit, Sant'Andrea University Hospital, via di Grottarossa 1035-1039, 00189 Rome, Italy

Publications

• Case Report   
  Electrochemotherapy in The Treatment of Melanoma and Non-Melanoma Cancer: The Synergistic Effect with Immunotherapy-A Series of Clinical Cases
  Author(s): Monia Specchia*, Denise Drittone, Eva Mazzotti* and Federica Mazzuca
  
  Objective: In the current oncologic landscape, where immunotherapy plays a central role in the management of both melanoma and non-melanoma skin cancers across various clinical settings, we explored the potential added value of Electrochemotherapy (ECT) as a loco-regional treatment. Can ECT, by enhancing the intracellular delivery of chemotherapeutic agents via reversible electroporation, offer synergistic benefits when integrated with systemic immunotherapeutic strategies? In this study we presented three cases of patients with advanced cutaneous malignancies treated with ECT in combination with Immune Checkpoint Inhibitors (ICIs), with the aim of exploring the therapeutic potential of this multimodal strategy. Methods: Three patients diagnosed with squamous cell carcinoma or melanoma underwent one or more ECT procedures alongside systemic .. View More»
  DOI: 10.35248/2167-0870.25.15.594

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